Short-term intensified training temporarily impairs mitochondrial respiratory capacity in elite endurance athletes
Daniele A. Cardinale, Kasper Degn Gejl, Kristine G. Petersen, Joachim Nielsen, Niels Ørtenblad, Filip J. Larsen
Abstract
We show that mitochondrial respiration is temporarily impaired after a period of intensified exercise training in elite athletes. In parallel, proteins involved in the antioxidative response including SOD2, UCP3, and ANT2 were upregulated, whereas mitochondrial biogenesis was slightly activated. Despite the mitochondrial respiratory impairments, physical performance was improved a few days after the intense training period.
Topics & Concepts
UCP3Endurance trainingMitochondrial biogenesisSOD2TFAMRespiratory systemElite athletesRespirationAthletesMitochondrionNRF1MedicinePhysiologyPhysical therapyBiologyInternal medicineUncoupling proteinCell biologyAnatomyOxidative stressBrown adipose tissueObesitySuperoxide dismutaseAdipose Tissue and MetabolismExercise and Physiological ResponsesMitochondrial Function and Pathology