A base-catalyzed approach for the anti-Markovnikov hydration of styrene derivatives
Spencer P. Pajk, Zisong Qi, Stephen J. Sujansky, Jeffrey S. Bandar
Abstract
The base-catalyzed addition of 1-cyclopropylethanol to vinyl (hetero)arenes sequenced with an acidic reaction workup enables anti-Markovnikov hydration in a complementary fashion to traditional hydroboration/oxidation protocols.
Topics & Concepts
Markovnikov's ruleCatalysisStyreneChemistryBase (topology)Combinatorial chemistryOrganic chemistryRegioselectivityMathematicsCopolymerPolymerMathematical analysisOrganoboron and organosilicon chemistryAsymmetric Hydrogenation and CatalysisChemical Synthesis and Reactions