Amyloid-β and p-Tau Anti-Threat Response to Herpes Simplex Virus 1 Infection in Primary Adult Murine Hippocampal Neurons
Rebecca D. Powell-Doherty, Amber Abbott, Laura A. Nelson, Andrea S. Bertke
Abstract
Growing evidence supports a link between HSV-1 infection and Alzheimer's disease (AD). Although AD is clearly a complex multifactorial disorder, an infectious disease etiology provides alternative therapy opportunities for this devastating disease. Understanding the impact that HSV-1 has on mature neurons and the proteins most strongly associated with AD pathology may identify specific mechanisms that could be manipulated to prevent progression of neurodegeneration and dementia.
Topics & Concepts
Herpes simplex virusNeurodegenerationBiologyDiseaseImmunologyVirologyAlzheimer's diseaseDementiaAmyloid (mycology)Hippocampal formationNeuroscienceVirusPathologyMedicineBotanyHerpesvirus Infections and TreatmentsMultiple Sclerosis Research StudiesRNA regulation and disease