Organophotoelectrocatalytic C(sp<sup>2</sup>)–H alkylation of heteroarenes with unactivated C(sp<sup>3</sup>)–H compounds
Qinhui Wan, Xia-Die Wu, Zhong-Wei Hou, Yongmin Ma, Lei Wang
Abstract
)-H alkylation combines organic catalysis, photochemistry and electrochemistry, avoiding the need for external metal-reagents, HAT-reagents, and oxidants. This protocol exhibits good substrate tolerance and functional group compatibility, providing a straightforward and powerful pathway to access a variety of alkylated heteroarenes under green conditions.
Topics & Concepts
AlkylationChemistryMedicinal chemistryStereochemistryOrganic chemistryCatalysisRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions