Progressive Encephalomyelitis With Rigidity and Myoclonus With Thymoma: A Case Report and Literature Review
Yana Su, Li Cui, Mingqin Zhu, Yixuan Liang, Ying Zhang
Abstract
Progressive encephalomyelitis with rigidity and myoclonus (PERM) is part of the variant type of the Stiff Person Syndrome (SPS) and is a rare neurological disease. We report here a patient with PERM who had thymoma and was positive for anti-glutamic acid decarboxylase (anti-GAD) antibodies. Her symptoms improved after treatment with hormones and gamma globulin. We also summarized the literature review of patients with PERM accompanied by tumors reported.
Topics & Concepts
Stiff person syndromeMyoclonusEncephalomyelitisMedicineThymomaDiseasePathologyGlutamate decarboxylaseImmunologyMultiple sclerosisAnesthesiaBiologyEnzymeBiochemistryAutoimmune Neurological Disorders and TreatmentsGlycogen Storage Diseases and MyoclonusGenetics and Neurodevelopmental Disorders