Genomic Profiling of Evolving Daptomycin Resistance in a Patient with Recurrent Staphylococcus argenteus Sepsis
Samantha Hao, Mazin Abdelghany, Amy Lyden, Rene Sit, Michelle Tan, Cristina M. Tato, Joseph L. DeRisi, Steve Miller, Sarah B. Doernberg, Charles Langelier
Abstract
Staphylococcus argenteus is a novel staphylococcal species associated with invasive disease. We report the first case of daptomycin/vancomycin-resistant S. argenteus , initially speciated as Staphylococcus aureus , that developed from repeated treatment with daptomycin for a complex vascular graft infection. Whole-genome sequencing of longitudinally collected isolates identified acquisition of MprF S337L, a mutation predicted to increase surface charge and repel cationic molecules.
Topics & Concepts
DaptomycinSepsisBiologyStaphylococcus aureusAntibiotic resistanceMicrobiologyGeneticsStaphylococcal infectionsMedicineComputational biologyBacteriaAntibioticsVancomycinImmunologyAntimicrobial Resistance in StaphylococcusBacterial biofilms and quorum sensing