Deletion of <i>cox7c</i> Results in Pan-Azole Resistance in Aspergillus fumigatus
Mingcong Chen, Guowei Zhong, Sha Wang, Peiying Chen, Lei Li
Abstract
In Aspergillus fumigatus , the most prevalent resistance to azoles results from mutational modifications of the azole target protein Cyp51A, but there are non- cyp51A mutants resistant to azoles, and the mechanisms underlying the resistance of these strains remain to be explored. Here, we identified a novel cytochrome c oxidase, cox7c (W56*), nonsense mutation in the laboratory and found that it caused reduced colony growth and resistance to multiantifungal agents.
Topics & Concepts
Aspergillus fumigatusItraconazoleAzoleBiologyMicrobiologyMutantErgosterolPosaconazoleDrug resistanceGeneBiochemistryAntifungalAntifungal resistance and susceptibilityFungal Biology and ApplicationsFungal and yeast genetics research