Catalyst‐Free, Radical Tri‐ and Difluoromethylation of Isocyanides and <i>N</i>‐Arylacrylamides Using Rotating Magnetic Field and Metal Rods
Xuliang Han, Haodong Liu, Xiaomei Feng, Fuchao Jia, Zengdian Zhao, Xinjin Li
Abstract
Comprehensive Summary The pursuit of sustainable and environmentally benign synthetic methods continues to challenge organic chemists. Herein, we introduce a magnetoredox system for tri‐ and difluoromethylation of isocyanides and N ‐arylacrylamides using a rotating magnetic field and steel rods. This magnetoredox approach enables facile synthesis of functionalized phenanthridines and oxindoles without the need for catalysts and additives under mild conditions. Such a system potentially represents an attractive strategy for selective formation of bonds through multifaceted regulation of magnetic intensity, rotating frequency, and rod size.
Topics & Concepts
ChemistryMetalRodMagnetic fieldField (mathematics)CatalysisNanotechnologyAerospace engineeringComputational chemistryOrganic chemistryQuantum mechanicsMaterials sciencePhysicsAlternative medicineEngineeringPure mathematicsMathematicsMedicinePathologyFluorine in Organic ChemistryInorganic Fluorides and Related CompoundsRadical Photochemical Reactions