Ruthenium complexes with <i>mono-</i> or <i>bis</i> -heterocyclic chelates: DNA/BSA binding, antioxidant and anticancer studies
Sanam Maikoo, Abir Chakraborty, Nyeleti Vukea, Laura Margaret Kirkpatrick Dingle, William John Samson, Jo‐Anne de la Mare, Adrienne L. Edkins, Irvin Noel Booysen
Abstract
). Radical scavenging studies revealed that the metal complexes have high activities towards the neutralization of NO and DPPH radicals. Data attained from the BSA electronic spectrophotometric titrations for the majority of the metal complexes illustrated distinct hyperchromism accompanied with blue shifts which indicates unwinding of the protein strands. Predominately, the metal complexes showed moderate cytotoxicity against both triple-negative breast cancer and cervical cancer cell lines that was greater than that of 5-fluorouracil.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
ChemistryRutheniumAgarose gel electrophoresisBinding constantBovine serum albuminTitrationMetalChelationDNAFluorescenceGel electrophoresisPhotochemistryCrystallographyInorganic chemistryBinding siteOrganic chemistryChromatographyBiochemistryQuantum mechanicsCatalysisPhysicsMetal complexes synthesis and propertiesProtein Interaction Studies and Fluorescence AnalysisDNA and Nucleic Acid Chemistry