Mechanistic insights on clearance and inhibition discordance between liver microsomes and hepatocytes when clearance in liver microsomes is higher than in hepatocytes
Christopher Keefer, George Chang, Anthony Carlo, Jonathan J. Novak, Michael J. Banker, Jackie Carey, Julie Cianfrogna, Heather Eng, Caitlin Jagla, Nathaniel Johnson, Rhys Jones, Samantha Jordan, Sarah Lazzaro, Jianhua Liu, R. Scott Obach, Keith Riccardi, David A. Tess, John P. Umland, Jillian Racich, Manthena V. S. Varma, Ravi Visswanathan, Li Di
Topics & Concepts
MicrosomeIC50EffluxIn vivoHepatocyteChemistryPharmacologyMetabolismCYP3ACytochrome P450Permeability (electromagnetism)BiochemistryIn vitroBiologyMembraneBiotechnologyDrug Transport and Resistance MechanismsPharmacogenetics and Drug MetabolismLiver Disease Diagnosis and Treatment