Rationally designed donepezil-based hydroxamates modulate Sig-1R and HDAC isoforms to exert anti-glioblastoma effects
Kunal Nepali, An-Chih Wu, Wei‐Lun Lo, Bhawna Chopra, Mei-Jung Lai, Jian‐Ying Chuang, Jing‐Ping Liou
Topics & Concepts
ChemistryPharmacologyDonepezilIn vivoProgrammed cell deathHydroxamic acidApoptosisHistone deacetylaseCancer researchBiochemistryStereochemistryHistoneMedicineBiologyDementiaBiotechnologyPathologyGeneDiseaseHistone Deacetylase Inhibitors ResearchCholinesterase and Neurodegenerative DiseasesGlioma Diagnosis and Treatment