Fine-tuning the cytotoxicity of ruthenium(<scp>ii</scp>) arene compounds to enhance selectivity against breast cancers
Sarah A. P. Pereira, Jan Romano‐deGea, Ana Isabel Barbosa, Sofia A. Costa Lima, Paul J. Dyson, M. Lúcia M.F.S. Saraiva
Abstract
A ruthenium(ii) arene compound was identified as the most promising candidate for breast cancer treatment amongst a library of rationally designed and fully synthesized compounds where the impact of different counterions’ cytotoxicity was evaluated.
Topics & Concepts
CytotoxicityRutheniumChemistryTolueneSelectivityBreast cancerCancer researchCombinatorial chemistryStereochemistryCancerIn vitroBiochemistryBiologyOrganic chemistryMedicineInternal medicineCatalysisMetal complexes synthesis and propertiesFerrocene Chemistry and ApplicationsClick Chemistry and Applications