[<sup>18</sup>F]CB251 PET/MR imaging probe targeting translocator protein (TSPO) independent of its Polymorphism in a Neuroinflammation Model
Kyungmin Kim, Heon Kim, Sung-Hwan Bae, Seok-Yong Lee, Young-Hwa Kim, Juri Na, Chulhee Lee, Min Sun Lee, Guen Bae Ko, Kyeong Yun Kim, Sang‐Hee Lee, In Ho Song, Gi Jeong Cheon, Keon Wook Kang, Sang Eun Kim, June-Key Chung, Euishin Edmund Kim, Sun-Ha Paek, Jae Sung Lee, Byung Chul Lee, Hyewon Youn
Abstract
F]CB251-PET/MRI, tested for evaluating the efficacy of anti-inflammatory agents in preclinical studies, might be an effective method to assess the severity and therapeutic response of neuroinflammation.
Topics & Concepts
Translocator proteinNeuroinflammationPet imagingPositron emission tomographyMedicineMolecular imagingPathologyChemistryNuclear magnetic resonanceMolecular biologyNuclear medicineBiologyInflammationPhysicsInternal medicineGeneticsIn vivoCerebrospinal fluid and hydrocephalusNeonatal and fetal brain pathologyTraumatic Brain Injury and Neurovascular Disturbances