Chemical and biological studies on the soft coral<i>Nephthea</i>sp.
Omnia Hesham Abdelhafez, John Refaat Fahim, Ramy R. El Masri, M. Alaraby Salem, Samar Yehia Desoukey, Safwat A. Ahmed, Mohamed Salah Kamel, Sheila Marie Pimentel‐Elardo, Justin R. Nodwell, Usama Ramadan Abdelmohsen
Abstract
The cytotoxic potential of the crude extract, different fractions, and green synthesized nanoparticles of the soft coral<italic>Nephthea</italic>sp. was studied, supported by LC-HR-ESI-MS metabolomics analysis and molecular docking of the dereplicated compounds.
Topics & Concepts
CoralChemistryA549 cellMetabolomicsSKBR3Growth inhibitionIC50Cell cultureHL60TerpenoidCancer cellCell growthHuman breastBiochemistryStereochemistryIn vitroBiologyCancerChromatographyEcologyGeneticsMarine Sponges and Natural ProductsMicrobial Natural Products and BiosynthesisComputational Drug Discovery Methods