Computational model of cardiomyocyte apoptosis identifies mechanisms of tyrosine kinase inhibitor-induced cardiotoxicity
Monika E. Grabowska, Bryan Chun, Raquel Moya, Jeffrey J. Saucerman
Topics & Concepts
SorafenibApoptosisCancer researchTyrosine kinaseTyrosine-kinase inhibitorCardiotoxicityPlatelet-derived growth factor receptorPharmacologySunitinibProtein kinase BPI3K/AKT/mTOR pathwaySignal transductionMedicineChemistryBiologyCell biologyInternal medicineCancerReceptorBiochemistryChemotherapyHepatocellular carcinomaGrowth factorChemotherapy-induced cardiotoxicity and mitigationChronic Myeloid Leukemia TreatmentsSynthesis of Tetrazole Derivatives