Mortalin/Hspa9 involvement and therapeutic perspective in Parkinson’s disease
Marion Szelechowski, Baptiste Texier, Morgane Prime, Djamaa Atamena, Pascale Belenguer
Abstract
By controlling the proper folding of proteins imported into mitochondria and ensuring crosstalk between the reticulum and mitochondria to modulate intracellular calcium fluxes, Mortalin is a chaperone protein that plays crucial roles in neuronal homeostasis and activity. However, its expression and stability are strongly modified in response to cellular stresses, in particular upon altered oxidative conditions during neurodegeneration. Here, we report and discuss the abundant literature that has highlighted its contribution to the pathophysiology of Parkinson's disease, as well as its therapeutic and prognostic potential in this still incurable pathology.
Topics & Concepts
Perspective (graphical)DiseaseParkinson's diseaseMedicineBioinformaticsNeuroscienceComputer sciencePsychologyBiologyInternal medicineArtificial intelligenceMitochondrial Function and PathologyAlzheimer's disease research and treatmentsSignaling Pathways in Disease