Substrate-induced DMSO activation and subsequent reaction for rapid construction of substituted pyrimidines
Anan Wang, Xuesong Liu, Yi Kong, Jing Wang, Taoshan Jiang
Abstract
A metal-free direct synthesis of pyrimidines from amidine hydrochlorides, ketones and DMSO through substrate-induced DMSO activation and involved reactions has been developed.
Topics & Concepts
ChemistryAmidineSubstrate (aquarium)MetalCombinatorial chemistryReaction conditionsOrganic chemistryCatalysisGeologyOceanographyCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsChemical Synthesis and Analysis