Iridium‐Catalyzed Enantioselective Hydroarylation of Alkenes through C−H bond Activation: Experiment and Computation
Valmik S. Shinde, Manoj V. Mane, Luigi Cavallo, Magnus Rueping
Abstract
A new catalytic enantioselective hydroarylation of unactivated olefins is developed that provides rapid access to functionalized chiral dihydrobenzofurans with good yields and excellent enantioselectivities. Simple aromatic ketones or amides act as a directing group allowing the regioselective reaction at the more hindered ortho position. Tertiary benzylic stereocenters are obtained directly under mild reaction conditions and with complete atom economy from readily available starting materials.
Topics & Concepts
StereocenterEnantioselective synthesisCatalysisIridiumRegioselectivityAtom economyChemistryCombinatorial chemistryOrganic chemistryCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisSynthesis and Catalytic Reactions