Activation of α7 nAChR by PNU-282987 improves synaptic and cognitive functions through restoring the expression of synaptic-associated proteins and the CaM-CaMKII-CREB signaling pathway
Xiaoling Wang, Yuxin Deng, Yu-Mei Gao, Yang‐Ting Dong, Fan Wang, Zhi-Zhong Guan, Wei Hong, Xiaolan Qi
Abstract
signaling pathway, and improvement of the cognitive abilities of APP/PS1_DT mice.
Topics & Concepts
CREBHippocampusCell biologySynapseChemistrySignal transductionNeuroscienceDownregulation and upregulationBiologyTranscription factorBiochemistryGeneNicotinic Acetylcholine Receptors StudyCholinesterase and Neurodegenerative DiseasesNeuroscience and Neuropharmacology Research