The Fascinating Interplay between Growth Hormone, Insulin-Like Growth Factor-1, and Insulin
Eline C. Nijenhuis-Noort, Kirsten A. Berk, Sebastian Neggers, A. J. van der Lely
Abstract
This review intends to provide the reader with a practical overview of several (patho)physiological conditions in which knowledge of the interplay between growth hormone (GH), insulin-like growth factor-1 (IGF-1), and insulin is important. This might help treating physicians in making the right decisions on how to intervene and improve metabolism for the benefit of patients, and to understand why and how metabolism responds in their specific cases. We will specifically address the interplay between GH, IGF-1, and insulin in type 1 and 2 diabetes mellitus, liver cirrhosis, and acromegaly as examples in which this knowledge is truly necessary.
Topics & Concepts
AcromegalyGrowth hormoneInsulinInsulin-like growth factorMedicineGrowth factorEndocrinologyDiabetes mellitusHormoneCirrhosisType 2 Diabetes MellitusCarbohydrate metabolismInternal medicineBioinformaticsBiologyReceptorGrowth Hormone and Insulin-like Growth FactorsMetabolism, Diabetes, and CancerPituitary Gland Disorders and Treatments