Drug interactions with cannabinoids
Tony Antoniou, Jack Bodkin, Joanne Ho
Abstract
Delta-9-tetrahydrocannabinol (THC) and cannabidiol are pharmacologically active cannabinoids in marijuana that are metabolized by cytochrome P450 (CYP)3A4; THC is also metabolized by CYP2C9, a liver enzyme.[1][1] A pharmacokinetic study found that the CYP3A4 inhibitor ketoconazole nearly doubled THC
Topics & Concepts
CannabidiolKetoconazoleCYP3A4Cytochrome P450PharmacologyCannabinolTetrahydrocannabinolPharmacokineticsCannabinoidCYP2C9DrugChemistryMedicineCannabisEnzymeBiochemistryReceptorDermatologyAntifungalPsychiatryCannabis and Cannabinoid ResearchNeurotransmitter Receptor Influence on BehaviorForensic Toxicology and Drug Analysis