Catalytic Diastereo- and Enantioselective Synthesis of Tertiary Trifluoromethyl Carbinols through a Vinylogous Aldol Reaction of Alkylidenepyrazolones with Trifluoromethyl Ketones
Laura Carceller‐Ferrer, Aleix González del Campo, Carlos Vila, Gonzalo Blay, M. Carmen Muñoz, José R. Pedro
Abstract
H NMR and the enantiomeric excess by HPLC with the reaction time showed that full conversion of the starting materials is not achieved and that the enantiomeric excess decreases upon extended times, probably due to the reversibility of the reaction.
Topics & Concepts
TrifluoromethylChemistryEnantioselective synthesisAldol reactionNucleophileBifunctionalEnantiomerEnantiomeric excessOrganic chemistryTertiary alcoholsKetoneOrganocatalysisCatalysisAlkylFluorine in Organic ChemistryAsymmetric Synthesis and CatalysisSynthesis and Reactions of Organic Compounds