Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis
Fangyu Du, Wenjiao Sun, Christophe Morisseau, Bruce D. Hammock, Xuefei Bao, Qiu Liu, Chao Wang, Tan Zhang, Hao Yang, Jun Zhou, Wei Xiao, Zhongbo Liu, Guoliang Chen
Topics & Concepts
ChemistryEpoxide hydrolase 2PharmacophoreIn vivoStereochemistryDocking (animal)PotencyUreaPharmacologyAmideIn vitroEpoxide hydrolaseEnzymeBiochemistryNursingMedicineMicrosomeBiotechnologyBiologyEicosanoids and Hypertension PharmacologyHormonal Regulation and HypertensionFree Radicals and Antioxidants