Anion-responsive self-assembled hydrogels of a phenylalanine–TREN conjugate allow sequential release of propranolol and doxorubicin
Manas Kumar Pradhan, Deepika Gupta, Kavthekar Rupesh Namdev, Anjali, Chirag Miglani, Asish Pal, Aasheesh Srivastava
Abstract
anions induced a nanofiber-to-nanoglobule morphological change in the aqueous self-assemblies of NapF-TREN. However, upon ageing the samples, slow reformation of the nanofibers was also observed, reflecting the reversibility of the anion-gelator interaction. The anion- and pH-responsive nature of the NapF-TREN hydrogels was exploited to program sequential release of entrapped drugs propranolol and doxorubicin.
Topics & Concepts
ConjugateSelf-healing hydrogelsDoxorubicinPhenylalaninePropranololChemistryIonCombinatorial chemistryBiophysicsMaterials scienceNanotechnologyPolymer chemistryBiochemistryOrganic chemistryAmino acidMedicineChemotherapyBiologyInternal medicineMathematicsMathematical analysisSupramolecular Self-Assembly in MaterialsLuminescence and Fluorescent MaterialsMolecular Sensors and Ion Detection