Structure-based drug repositioning over the human TMPRSS2 protease domain: search for chemical probes able to repress SARS-CoV-2 Spike protein cleavages
Natesh Singh, Étienne Decroly, Abdel‐Majid Khatib, Bruno O. Villoutreix
Topics & Concepts
TMPRSS2Serine proteaseCoronavirusProteaseComputational biologyTransmembrane domainBiologySerineTransmembrane proteinChemistryVirologyEnzymeBiochemistryAmino acidCoronavirus disease 2019 (COVID-19)MedicineReceptorInfectious disease (medical specialty)DiseasePathologySARS-CoV-2 and COVID-19 Researchinterferon and immune responsesComputational Drug Discovery Methods