First-in-human evaluation of the novel mitochondrial complex I inhibitor ASP4132 for treatment of cancer
Filip Jankú, Patricia LoRusso, Aaron S. Mansfield, Rita Nanda, Alexander I. Spira, Tianli Wang, Amal Melhem‐Bertrandt, Jennifer Sugg, Howard Ball
Topics & Concepts
TolerabilityMedicinePharmacokineticsDosingCohortInternal medicineLactic acidosisGastroenterologyRefractory (planetary science)PharmacologyPharmacodynamicsAdverse effectPhysicsAstrobiologyMitochondrial Function and PathologyMetabolism, Diabetes, and CancerCancer, Hypoxia, and Metabolism