Metal‐Free and NBS‐Mediated Direct Thiol‐Disulfide Exchange Reaction to Access Unsymmetrical Disulfides
Ke Yang, Qingyue Hu, Qin Li, Junxiang Liu, Zhengyi Li, Bijin Li, Xiaoqiang Sun
Abstract
Abstract A metal‐free and N ‐Bromosuccinimide (NBS)‐mediated direct thiol‐disulfide exchange reaction at room temperature is developed. A variety of unsymmetrical disulfides have been prepared with good to excellent yields. Efficient late‐stage modification of amino acids and drugs demonstrates the utility of this strategy. In addition, easy to operate, broad substrate scope and good functional group tolerance further demonstrate that this reaction provides an essential complementary route to access unsymmetrical disulfides.
Topics & Concepts
ChemistryThiolDisulfide bondCombinatorial chemistryFunctional groupSubstrate (aquarium)MetalReaction conditionsOrganic chemistryCatalysisBiochemistryOceanographyGeologyPolymerSulfur-Based Synthesis TechniquesChemical Synthesis and ReactionsSynthesis and Catalytic Reactions