Aerobic oxidative C–H phosphorylation of quinoxalines under catalyst-free conditions
Qiaoyu Gan, Haibo Liu, Zeqi Jiang, Junmei Xia, Zhenhua Gao, Yongbiao Guo, Hongliang Wen
Abstract
We herein report a direct and efficient protocol for phosphorylation of quinoxalines, which employs aerobic oxygen as the green oxidant under catalyst-free conditions. This methodology represents one of the most environmentally friendly and easily handled protocols, providing a series of phosphorylated quinoxalines in good to excellent yields. Control experiments clearly indicated that the reaction followed a dearomatization-rearomatization strategy.
Topics & Concepts
Oxidative phosphorylationCatalysisChemistryPhosphorylationCombinatorial chemistryBiochemistrySynthesis and Biological EvaluationCatalytic C–H Functionalization MethodsFluorine in Organic Chemistry