Direct C(sp<sup>3</sup>)–H Cyanation Enabled by a Highly Active Decatungstate Photocatalyst
Kunsoon Kim, Seulchan Lee, Soon Hyeok Hong
Abstract
A highly efficient, direct C(sp3)–H cyanation was developed under mild photocatalytic conditions. The method enabled the direct cyanation of various C(sp3)–H substrates with excellent functional group tolerance. Notably, complex natural products and bioactive compounds were efficiently cyanated.
Topics & Concepts
CyanationChemistryPhotocatalysisPhotochemistryOrganic chemistryCatalysisCatalytic C–H Functionalization MethodsSynthesis and Catalytic ReactionsRadical Photochemical Reactions