Safety and immunogenicity of a plant-derived recombinant protective antigen (rPA)-based vaccine against Bacillus anthracis: A Phase 1 dose-escalation study in healthy adults
Kristopher Paolino, Jason A. Regules, James E. Moon, Richard C. Ruck, Jason W. Bennett, Shon Remich, Kristin T Mills, Leyi Lin, CaDeidre Washington, Ghariwayne A. Fornillos, Changhong Y. Lindsey, Kristan A. O’Brien, Meng Shi, R. Mark Jones, Brian J. Green, Stephen Tottey, Jessica A. Chichester, Stephen J. Streatfield, Vidadi Yusibov
Topics & Concepts
ImmunogenicityReactogenicityAnthrax vaccinesBacillus anthracisVaccinationAnthrax toxinMedicineAntigenAdjuvantImmune systemImmunologyImmunizationMicrobiologyVirologyBiologyRecombinant DNAFusion proteinDNA vaccinationGeneticsBacteriaGeneBiochemistryBacillus and Francisella bacterial researchTransgenic Plants and ApplicationsToxin Mechanisms and Immunotoxins