Relationship between central autonomic effective connectivity and heart rate variability: A Resting-state fMRI dynamic causal modeling study
Liangsuo Ma, Larry Keen, Joel L. Steinberg, David Eddie, Alex Y. Tan, Lori Keyser‐Marcus, Antonio Abbate, F. Gerard Moeller
Abstract
• Resting- state fMRI data were acquired from 34 healthy participants. • Effective connectivities (ECs) associated with HRV and heart rate were investigated. • Regression DCM and ICA were used to identify most relevant network nodes. • ECs related to HRV and heart rate were identified using spectral DCM. • ECs from amygdala to prefrontal cortex may regulate cardiodynamics during rest. The central autonomic network (CAN) serves as a regulatory hub with top-down regulatory control and integration of bottom-up physiological feedback via the autonomic nervous system. Heart rate variability (HRV)—the time variance of the heart's beat-to-beat intervals—is an index of the CAN's affective and behavioral regulatory capacity. Although neural functional connectivities that are associated with HRV and CAN have been well studied, no published report to date has studied effective (directional) connectivities (EC) that are associated with HRV and CAN. Better understanding of neural EC in the brain has the potential to improve our understanding of how the CAN sub-regions regulate HRV. To begin to address this knowledge gap, we employed resting-state functional magnetic resonance imaging and dynamic causal modeling (DCM) with parametric empirical Bayes analyses in 34 healthy adults (19 females; mean age= 32.68 years [ SD = 14.09], age range 18–68 years) to examine the bottom-up and top-down neural circuits associated with HRV. Throughout the whole brain, we identified 12 regions associated with HRV. DCM analyses revealed that the ECs from the right amygdala to the anterior cingulate cortex and to the ventrolateral prefrontal cortex had a negative linear relationship with HRV and a positive linear relationship with heart rate. These findings suggest that ECs from the amygdala to the prefrontal cortex may represent a neural circuit associated with regulation of cardiodynamics.