Efficient reactions for the synthesis of pyrazolo[3,4‐<scp><i>b</i></scp>]pyridine and pyrano[2,3‐<scp><i>c</i></scp>]pyrazole derivatives from <scp><i>N</i></scp>‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine
Yifan Ji, Li Li, Guang‐Zhou Zhu, Ya Zhou, Xinchi Lu, Wenjing He, Lijiu Gao, Liangce Rong
Abstract
Abstract The efficient and novel method for the synthesis of pyrazolo[3,4‐ b ]pyridine and pyrano[2,3‐ c ]pyrazole derivatives from the multicomponent reaction of aromatic aldehydes (isatins), N ‐methyl‐1‐(methylthio)‐2‐nitroethen‐1‐amine, and 3‐aminopyrazole or methyl 3‐hydroxy‐1 H ‐pyrazole‐5‐carboxylate under normal laboratory conditions was reported in this research. The advantages of this research are wide range of substrates, high yields, and simple operation.
Topics & Concepts
ChemistryPyrazolePyridineAmine gas treatingCombinatorial chemistryMedicinal chemistryOrganic chemistryStereochemistryMulticomponent Synthesis of HeterocyclesSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds