Nitroxide‐Catalyzed Oxidative Amidation of Aldehydes to Yield <i>N</i>‐Acyl Azoles Using Sodium Persulfate
Fabrizio Politano, Arturo León Sandoval, Mason L. Witko, Katrina E. Doherty, Chelsea M. Schroeder, Nicholas E. Leadbeater
Abstract
Abstract A methodology for the oxidative amidation of aldehydes to yield N ‐acyl azoles is reported. The approach employs sodium persulfate and a catalytic amount of a nitroxide and is applicable to a range of structurally diverse substrates.
Topics & Concepts
ChemistryYield (engineering)Nitroxide mediated radical polymerizationCatalysisPersulfateOxidative phosphorylationSodium persulfateOrganic chemistryCombinatorial chemistrySodiumBiochemistryCopolymerPolymerMaterials scienceMetallurgyRadical polymerizationChemical Synthesis and AnalysisSynthesis and Catalytic ReactionsChemical Synthesis and Reactions