Evaluation of SARS-CoV-2 Main Protease Inhibitors Using a Novel Cell-Based Assay
Wenyue Cao, Chia-Chuan Dean Cho, Zhi Geng, Namir Shaabani, R. Xinyu, Erol C. Vatansever, Yugendar R. Alugubelli, Yuying Ma, Sankar P. Chaki, William H. Ellenburg, Kai S. Yang, Yuchen Qiao, Robert D. Allen, Benjamin W. Neuman, Henry Ji, Shiqing Xu, Wenshe Ray Liu
Abstract
value of 30 nM. Therefore, we cautiously suggest exploring MPI8 further for COVID-19 preclinical tests.
Topics & Concepts
PotencyProteasePharmacologyProtease inhibitor (pharmacology)IC50ChloroquineProteasesChemistryEnzymeBiologyBiochemistryIn vitroVirologyVirusViral loadImmunologyAntiretroviral therapyMalariaSARS-CoV-2 and COVID-19 ResearchComputational Drug Discovery MethodsMosquito-borne diseases and control