Three-Component Ni-Catalyzed Silylacylation of Alkenes
Dongshun Ni, M. Kevin Brown
Abstract
A Ni-catalyzed silylacylation of alkenes is presented. The reaction combines alkenes, ClZnSiR3, and acid chlorides to provide rapid access to β-silyl ketones. Importantly, the method involves a [Ni]-SiR3 complex as a catalytic intermediate, which is rarely described for three-component alkene functionalization. Finally, the synthetic utility of the products is demonstrated, and the mechanistic details are described.
Topics & Concepts
CatalysisComponent (thermodynamics)ChemistryOrganic chemistryPhysicsThermodynamicsOrganoboron and organosilicon chemistryCatalytic C–H Functionalization MethodsChemical Synthesis and Reactions