Calmodulin disrupts plasma membrane localization of farnesylated KRAS4b by sequestering its lipid moiety
Benjamin Grant, Masahiro Enomoto, Sung-In Back, Ki‐Young Lee, Teklab Gebregiworgis, Noboru Ishiyama, Mitsuhiko Ikura, Christopher B. Marshall
Abstract
Calmodulin sequesters and inhibits KRAS4b by binding a lipid-modified region of the protein.
Topics & Concepts
CalmodulinMoietyChemistryCell biologyBiophysicsBiochemistryBiologyStereochemistryEnzymeProtein Kinase Regulation and GTPase SignalingProtein Structure and DynamicsReceptor Mechanisms and Signaling