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Factors associated with: problems of using exploratory multivariable regression to identify causal risk factors

Dan Lewer, Thomas D. Brothers, Elizabeth O’Nions, John Pickavance

2025BMJ Medicine7 citationsDOIOpen Access PDF

Abstract

Lewer and colleagues explain why risk factors for a health outcome should not be studied by putting several candidate independent variables (exposures) into a multivariable regression model and identifying which are statistically significant after mutual adjustment.

Topics & Concepts

Multivariable calculusRegression analysisRegressionOutcome (game theory)Linear regressionRisk factorLogistic regressionEconometricsCausality (physics)Computer scienceMedicineVariablesIdentification (biology)StatisticsTerm (time)Cross-sectional regressionCausal modelMultivariate statisticsFactor regression modelStatistical Methods in Epidemiology
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