SIRT4 Suppresses Doxorubicin-Induced Cardiotoxicity by Regulating the AKT/mTOR/Autophagy Pathway
Ling He, Jihong Wang, Yuting Yang, Pengtao Zou, Zirong Xia, Juxiang Li
Topics & Concepts
AutophagyPI3K/AKT/mTOR pathwayCardiotoxicityProtein kinase BDoxorubicinPharmacologyProgrammed cell deathApoptosisCancer researchReactive oxygen speciesmTORC2BiologyChemistryCell biologySignal transductionmTORC1BiochemistryChemotherapyGeneticsChemotherapy-induced cardiotoxicity and mitigationCalcium signaling and nucleotide metabolismElectron Spin Resonance Studies