Heat Shock Proteins as the Druggable Targets in Leishmaniasis: Promises and Perils
Pragya Prasanna, Arun Upadhyay
Abstract
Leishmania , the causative agent of leishmaniasis, is an intracellular pathogen that thrives in the insect gut and mammalian macrophages to complete its life cycle. Apart from temperature difference (26 to 37°C), it encounters several harsh conditions, including oxidative stress, inflammatory reactions, and low pH. Heat shock proteins (HSPs) play essential roles in cell survival by strategically reprogramming cellular processes and signaling pathways. HSPs assist cells in multiple functions, including differentiation, adaptation, virulence, and persistence in the host cell.
Topics & Concepts
BiologyLeishmaniaHeat shock proteinReprogrammingCell biologyVirulenceIntracellular parasiteIntracellularAmastigoteLeishmaniasisLeishmania majorDruggabilityMicrobiologyCellImmunologyGeneticsGeneParasite hostingComputer scienceWorld Wide WebHeat shock proteins researchResearch on Leishmaniasis StudiesInsect and Pesticide Research