Exploring Guanidinium Organocatalysts for Hypoiodite‐Mediated Reactions
Minami Odagi, Kazuo Nagasawa, Kazuo Nagasawa
Abstract
This account describes our recent work on developing guanidinium hypoiodite- catalysts for oxidative carbon-nitrogen and carbon-carbon bond-forming reactions. These reactions proceeded smoothly using guanidinium hypoiodite generated in situ by treating 1,3,4,6,7-hexahydro-2H-pyrimido[1,2-a]pyrimidine hydroiodide salts with an oxidant. In this approach, the ionic interaction and hydrogen bonding ability of the guanidinium cations enable bond-forming reactions that have been difficult with conventional methods. Enantioselective oxidative carbon-carbon bond-forming reaction was also achieved by using a chiral guanidinium organocatalyst.
Topics & Concepts
ChemistryEnantioselective synthesisCarbon fibersCatalysisIonic bondingHydrogen bondOrganocatalysisPyrimidineCombinatorial chemistryOrganic chemistryIonMoleculeStereochemistryMaterials scienceComposite numberComposite materialSynthesis and Catalytic ReactionsChemical Synthesis and AnalysisChemical Synthesis and Reactions