Clinical Features and Outcomes of Bloodstream Infections Caused by New Delhi Metallo-β-Lactamase–Producing Enterobacterales During a Regional Outbreak
Marco Falcone, Giusy Tiseo, Alberto Antonelli, Cesira Giordano, Vincenzo Di Pilato, Pietro Bertolucci, Eva Maria Parisio, Alessandro Leonildi, Noemi Aiezza, Ilaria Baccani, Enrico Tagliaferri, Lorenzo Righi, Silvia Forni, Spartaco Sani, Maria Teresa Mechi, Filippo Pieralli, Simona Barnini, Gian María Rossolini, Francesco Menichetti
Abstract
Limited data about New Delhi metallo-β-lactamase (NDM) bacteremia are available. Blood isolates from 40 patients with NDM bacteremia were studied for antibiotic susceptibility and whole-genomic sequencing. NDM bacteremia has high 30-day mortality. In most cases, aztreonam-avibactam is active in vitro. Ceftazidime-avibactam plus aztreonam may represent a feasible therapeutic option.
Topics & Concepts
AztreonamBacteremiaMedicineCeftazidimeCeftazidime/avibactamBloodstream infectionAntibioticsNew delhiOutbreakIntensive care medicineBlood cultureMicrobiologyInternal medicineVirologyBacteriaAntibiotic resistanceBiologyPseudomonas aeruginosaImipenemGeneticsPathologyMetropolitan areaAntibiotic Resistance in BacteriaAntibiotic Use and ResistanceBacterial Identification and Susceptibility Testing