HMGB1-mediated elevation of KLF7 facilitates hepatocellular carcinoma progression and metastasis through upregulating TLR4 and PTK2
Weibo Feng, Jie Chen, Wenjie Huang, Guodong Wang, Xilang Chen, Lili Duan, Yue Yin, Xiaoping Chen, Bixiang Zhang, Mengyu Sun, Xiangyuan Luo, Yongzhan Nie, Daiming Fan, Kaichun Wu, Limin Xia
Abstract
HMGB1-induced KLF7 overexpression facilitates HCC progression and metastasis by upregulating TLR4 and PTK2. Genetic ablation of KLF7 via AAV gene therapy and combined blockade of TLR4 and PTK2 represents promising therapy strategies for KLF7-positive HCC patients.
Topics & Concepts
HMGB1Cancer researchTLR4MetastasisBiologyTumor progressionCancerInflammationCell biologySignal transductionImmunologyGeneticsKruppel-like factors researchCancer-related gene regulationEpigenetics and DNA Methylation