m6A-induced LINC00958 promotes breast cancer tumorigenesis via the miR-378a-3p/YY1 axis
Dongwen Rong, Dong Qian, Huajun Qu, Xinna Deng, Fei Gao, Qingxia Li, Ping Sun
Abstract
Abstract Increasing evidence demonstrates that long noncoding RNAs (lncRNAs) play critical roles in human breast cancer (BC) tumorigenesis. However, the mechanisms by which lncRNA and N 6 -methyladenosine (m 6 A) regulate BC tumorigenesis are still unclear. In the present research, LINC00958 was markedly overexpressed in BC tissue and cells, and LINC00958 upregulation promoted the tumor progression of BC cells. Mechanistically, m 6 A methyltransferase-like 3 (METTL3) gave rise to the upregulation of LINC00958 by promoting its RNA transcript stability. Moreover, LINC00958 acted as a competitive endogenous RNA for miR-378a-3p to promote YY1. Overall, these data provide novel insight into how m 6 A-mediated LINC00958 regulates BC tumorigenesis.