Cardiac ryanodine receptor calcium release deficiency syndrome
Bo Sun, Jinjing Yao, Mingke Ni, Jinhong Wei, Xiaowei Zhong, Wenting Guo, Lin Zhang, Ruiwu Wang, Darrell D. Belke, Yong-Xiang Chen, Krystien V.V. Lieve, Anders Krogh Broendberg, Thomas M. Roston, Ivan Blankoff, Janneke A.E. Kammeraad, Johannes C. von Alvensleben, Julieta Lazarte, Alexander Vallmitjana, Loryn J. Bohne, Robert A. Rose, Raúl Benítez, Leif Hove‐Madsen, Carlo Napolitano, Robert A. Hegele, Michael Fill, Shubhayan Sanatani, Arthur A.M. Wilde, Jason D. Roberts, Silvia G. Priori, Henrik Kjærulf Jensen, S.R. Wayne Chen
Abstract
release deficiency syndrome (CRDS). Our study provides insights into the mechanism of CRDS, reports a specific CRDS diagnostic test, and identifies potentially efficacious anti-CRDS therapies.
Topics & Concepts
Ryanodine receptorCalciumReceptorMedicineEndocrinologyInternal medicineChemistryCardiac electrophysiology and arrhythmiasIon channel regulation and functionProtein Kinase Regulation and GTPase Signaling