Membrane Dynamics and Cation Handling in Ferroptosis
Yusuke Hirata, Eikan Mishima
Abstract
Ferroptosis, a regulated cell death hallmarked by excessive lipid peroxidation, is implicated in various (patho)physiological contexts. During ferroptosis, lipid peroxidation leads to a diverse change in membrane properties and the dysregulation of ion homeostasis via the cation channels, ultimately resulting in plasma membrane rupture. This review illuminates cellular membrane dynamics and cation handling in ferroptosis regulation.
Topics & Concepts
Lipid peroxidationHomeostasisMembraneCell biologyCell membraneChemistryGPX4CellBiophysicsMembrane lipidsBiochemistryProgrammed cell deathBiologyOxidative stressApoptosisGlutathione peroxidaseCatalaseFerroptosis and cancer prognosisCancer, Lipids, and MetabolismRNA modifications and cancer