Keratin 17 covalently binds to alpha-enolase and exacerbates proliferation of keratinocytes in psoriasis
Yi Luo, Bingyu Pang, Junfeng Hao, Qingyang Li, Pei Qiao, Chen Zhang, Yaxing Bai, Chunying Xiao, Jiaoling Chen, Dalong Zhi, Ying Liu, Erle Dang, Gang Wang, Bing Li
Abstract
. These findings provide new insights into the metabolic profile of psoriatic KCs and suggest that modulation of the ENO1-K17-LDHA axis is a potentially innovative therapeutic approach to psoriasis.
Topics & Concepts
PsoriasisGlycolysisPhosphorylationGene knockdownBiologyCancer researchMolecular biologyChemistryCell biologyBiochemistryEnzymeImmunologyGeneSkin and Cellular Biology ResearchPsoriasis: Treatment and PathogenesisRetinoids in leukemia and cellular processes