Developments in oral enterotoxigenic Escherichia coli vaccines
Ann‐Mari Svennerholm, Anna Lundgren
Abstract
Enterotoxigenic Escherichia coli (ETEC) is a leading cause of diarrhea in children in developing countries and in travelers. WHO has affirmed ETEC as a priority vaccine target, but there is no licensed ETEC vaccine available yet. We here describe recent, promising developments of different live, inactivated, and subunit ETEC candidate vaccines expressing or containing nontoxic enterotoxin and/or colonization factor antigens with a focus on oral vaccines. Many of the ETEC candidate vaccines have been tested in clinical trials for safety and immunogenicity and some of them also for protective efficacy in field trials or in challenge studies.
Topics & Concepts
Enterotoxigenic Escherichia coliEnterotoxinImmunogenicityDiarrheaMicrobiologyVirologyMedicineEscherichia coliBiologyAntigenImmunologyGeneticsGeneInternal medicineEscherichia coli research studiesViral gastroenteritis research and epidemiologyAntibiotic Resistance in Bacteria