Substituted 1-methyl-4-phenylpyrrolidin-2-ones – Fragment-based design of N-methylpyrrolidone-derived bromodomain inhibitors
J.P. Hilton-Proctor, O.V. Ilyichova, Zhaohua Zheng, Ian G. Jennings, Ricky W. Johnstone, Jake Shortt, Simon J. Mountford, M.J. Scanlon, Philip E. Thompson
Topics & Concepts
BromodomainChemistryStereochemistryChemotypeArylChemical synthesisCombinatorial chemistryBiochemistryIn vitroOrganic chemistryEpigeneticsChromatographyAlkylEssential oilGenePeptidase Inhibition and AnalysisProtein Degradation and InhibitorsHIV/AIDS drug development and treatment