The stem/progenitor landscape is reshaped in a mouse model of essential thrombocythemia and causes excess megakaryocyte production
Daniel Prins, Hyun Jung Park, Sam Watcham, Juan Li, Michèle Vacca, Hugo Bastos, Alexander Gerbaulet, Antonio Vidal‐Puig, Berthold Göttgens, Anthony R. Green
Abstract
mutations to increased HSC proliferation and megakaryopoiesis.
Topics & Concepts
MegakaryocyteEssential thrombocythemiaHaematopoiesisProgenitor cellProgenitorStem cellBiologyMutantProduction (economics)Cell biologyPolycythemia veraImmunologyGeneticsGeneMacroeconomicsEconomicsMyeloproliferative Neoplasms: Diagnosis and TreatmentPlatelet Disorders and TreatmentsKruppel-like factors research