A novel peptide exerts potent immunosuppression by blocking the two-site interaction of NFAT with calcineurin
Lu Wang, Na Cheng, Ping Wang, Jing Li, Anna Jia, Wenying Li, Nan Zhang, Yanxia Yin, Tong Li, Qun Wei, Guangwei Liu, Zhimei Li, Jing Luo
Abstract
IT-mediated anchoring to CN. Expression of this peptide significantly suppresses CN/NFAT signaling. Cell-permeable 11-arginine-modified pep3 (11R-pep3) blocks the NFAT downstream signaling pathway. Intranasal administration of the 11R-pep3 peptide inhibits airway inflammation in an ovalbumin-induced asthma model. Our results suggest that pep3 is promising as an immunosuppressive agent and can be used in topical remedies.
Topics & Concepts
NFATMicroscale thermophoresisCalcineurinCell biologyDocking (animal)PeptideSignal transductionChemistryBiologyTranscription factorBiochemistryTransplantationMedicineNursingSurgeryGeneSignaling Pathways in DiseasePeptidase Inhibition and AnalysisNeuropeptides and Animal Physiology